Welcome to the Luca Lab website!
We are interested in understanding the genetic and molecular basis of inter-individual and inter-population differences in complex phenotypes of biomedical interest.
We combine evolutionary and functional genomics approaches to study intermediate phenotypes (e.g.: transcription factor binding, gene expression, chromatin accessibility) and how they are affected by gene-environment interactions.
We are a diverse group of people with different backgrounds, skills and strengths. We value our diversity. We care about you as human beings. We do not tolerate harassment, belittlement, or discrimination of any kind.
Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions
Findley et al https://doi.org/10.1101/2021.01.29.428868
Psychosocial experiences modulate asthma-associated genes through gene-environment interactions
Resztak et al
Interspecies variation in hominid gut microbiota controls host gene regulation
Muehlbauer et al