Welcome to the Luca Lab website!
We are interested in understanding the genetic and molecular basis of inter-individual and inter-population differences in complex phenotypes of biomedical interest.
We combine evolutionary and functional genomics approaches to study intermediate phenotypes (e.g.: transcription factor binding, gene expression, chromatin accessibility) and how they are affected by gene-environment interactions.
Interpreting coronary artery disease risk through gene-environment interactions in gene regulation.
Findley et al. https://doi.org/10.1534/genetics.119.302419
High throughput characterization of genetic effects on DNA:protein binding and gene transcription.
Kalita et al 2018 Genome Res.
Gut microbiota has a widespread and modifiable effect on host gene regulation
Richards et al. https://doi.org/10.1128/mSystems.00323-18