We recently moved to the University of Chicago. Get in touch if you would like to join us in the Windy City!
Welcome to the Luca Lab website!
We are interested in understanding the genetic and molecular basis of differences among individuals and among groups in complex phenotypes of biomedical interest. We combine evolutionary and functional genomics approaches to study intermediate phenotypes (e.g.: transcription factor binding, gene expression, chromatin accessibility) and how they are affected by gene-environment interactions.
We are a diverse group of people with different backgrounds, skills and strengths. We value our diversity. We care about you as human beings. We do not tolerate harassment, belittlement, or discrimination of any kind.
Recent Publications
Characterization of caffeine response regulatory variants in vascular endothelial cells
Boye et al https://doi.org/10.7554/eLife.85235
Genotype × environment interactions in gene regulation and complex traits
Boye, Nirmalan, Ranjbaran & Luca https://www.nature.com/articles/s41588-024-01776-w
Functional characterization of eQTLs and asthma risk loci with scATAC-seq across immune cell types and contexts
Wei et al DOI: 10.1016/j.ajhg.2024.12.017
Luca Lab 